The afikomen (meaning 'desert') is the last matzo to be eaten during the Seder meal. Before the meal, this matzo is wrapped in a linen cloth, broken and hidden somewhere within the room where the meal is being eaten. Towards the end of the meal, members of the family, usually the children, are sent to find the afikomen. The meal cannot continue until it is found. Whoever finds the afikomen is given a reward, which is usually money. After it has been found, everyone around the table is given a piece of the afikomen to eat.

Many experts believe that the matzo which Jesus broke with the words, "This is my body" was the afikomen.

During the Seder meal, the eating of the afikomen is followed by another drink of wine. Jews call this drink the 'Cup of Freedom'. Jesus said this cup of wine stood for his blood, which for many people, would bring freedom from sin.